6 research outputs found
Geographical influences on the association between adherence to the Mediterranean diet and the prevalence of acute coronary syndromes, in Greece: The CARDIO2000 study
Objective: We evaluated the interaction between adherence to the
Mediterranean diet and region of Greece on the likelihood of having
acute coronary syndromes (ACS).
Methods: During 2000-2001, a random sample of 848 patients (61 10 years)
with their first coronary heart disease event, and 1078 frequency
matched (by age-sex) controls with no cardiovascular disease in their
medical history, from all the country, entered into the study. Among
several factors, adherence to the Mediterranean diet was assessed by a
diet-score that incorporated the inherent characteristics of this diet.
Results: The multi-adjusted analysis showed that a 10-unit increase in
the diet score was associated with a 27% (95% CI 0.66 to 0.89)
decrease of the odds of having ACS. Moreover, a highly significant
interaction was observed between region and diet score (p < 0.001). The
odds ratios varied from roughly 0.5 in Southern to 1.2 or more in
Northern Greek regions (p for heterogeneity < 0.05). Differences in food
patterns consumed did not explain the previous findings. In addition,
when we stratified our analysis by rural and urban areas we found
significant differences in the estimated odds ratios (p for interaction
between diet score and area=0.01), since a 10-unit increase in the diet
score was associated with 22% (95% CI 0.63 to 0.96) lower odds n urban
areas and 31% (95% CI 0.48 to 0.98) lower odds in rural areas.
Conclusion: Our findings underline the significance of the Mediterranean
diet on the primary prevention of ACS. Moreover, we revealed a
geographical variation in the importance of this dietary pattern on
coronary risk, independent from the composition of food patterns
followed and the prevalence of the common cardiovascular risk factors.
(c) 2005 Elsevier Ireland Ltd. All rights reserved